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Thereafter, the dose should be adjusted individually according to the clinical findings and thyroid hormone and TSH values.įor children with acquired hypothyroidism, the initial recommended dosage is 12.5-50 micrograms per day. Infants should be given the total daily dose at least half an hour before the first meal of the day.įor neonates and infants with congenital hypothyroidism, where rapid replacement is important, the initial recommended dosage is 10 to 15 micrograms per kg BW per day for the first 3 months. Regular monitoring using serum TSH levels, as in adults, is required to make sure he/she gets the right dose.

The dose for children depends on their age, weight and the condition being treated. The maintenance dose is generally 100 to 150 micrograms per m² body surface area. The final daily dose may be up to 50 to 200 micrograms.įor patients aged over 50 years, with or without cardiac disease, clinical response is probably a more acceptable criteria of dosage rather that serum levels. In this conditions, the daily dose may be increased by 25 micrograms at intervals of every 4 weeks, until stable thyroxine levels are attained. Where there is cardiac disease, 25 micrograms daily or 50 micrograms on alternate days is more suitable. Patients over 50 years with cardiac disease The final daily dose may be up to 50 to 200 micrograms. In this condition, the daily dose may be increased by 50 micrograms at intervals of every 3-4 weeks, until stable thyroxine levels are attained. The final daily dose may be up to 100 to 200 micrograms.įor patients over 50 years, initially, it is not advisable to exceed 50 micrograms daily. Adjust at three to four week intervals by 50 micrograms until normal metabolism is steadily maintained. Initially 100 micrograms daily, preferably taken before breakfast or the first meal of the day. If too rapid an increase in metabolism is produced (causing diarrhoea, nervousness, rapid pulse, insomnia, tremors, and sometimes anginal pain where there is latent cardiac ischaemia,) dosage must be reduced, or withheld, for a day or two, and then re-started at a lower dose level.

A pre-therapy ECG is valuable because ECG changes due to hypothyroidism may be confused with ECG evidence of cardiac ischaemia. In younger patients, and in the absence of heart disease, a serum Levothyroxine (T4) level of 70 to 160 nanomols per litre, or a serum thyrotrophin level of less that 5 milli-units per litre should be targeted. Date of first authorisation/renewal of the authorisation 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.